The series follows Lucifer Morningstar (played by Tom Ellis), the Devil, who becomes bored with his life as the ruler of Hell and decides to retire to Los Angeles. There, he opens a luxurious nightclub called Lux and indulges in a life of pleasure and hedonism.

However, after witnessing a murder outside his club, Lucifer becomes intrigued by the concept of justice and starts working with LAPD homicide detective Chloe Decker (Lauren German). Together, they solve crimes, with Lucifer using his supernatural abilities, including his power to compel people to reveal their deepest desires. The partnership leads to a complex relationship filled with tension, humor, and romance.